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Defeat the Blot is a Quest given before Mickey fights the Shadow Blot. This also the final Quest of the game.

Mickey must activate the fireworks and gargoyles and do more stuff, enter the Blot, redeem or defeat the Blotlings, get the Gremlin Guardian Pin after freeing the all of Gus' friends (excluding Markus), destroy the Bloticles and let the Lost Characters melt, redeem or defeat more Blotlings and destroy all the Bloticles and the Blot will drop Mickey's Heart to finish the game and the Quest.