Defeat the Slobber is a Quest Mickey obtains when he enters the Great Big Tomorrow exhibit in Tomorrow City.

Mickey must toss Paint or Thinner at the Slobber. He shouldn't get too close to him as he will use his claws. When he tries to inhale Mickey, he must spray Paint or Thinner into his mouth. Also, he must avoid the Thinner shot by him. He must keep using Paint or Thinner while he's inhaling until he's defeated or redeemed. The quest is completed once Mickey has dealt with the Slobber. The way he chose to deal with the Slobber changes the contents of the treasure chest given by Mister Rover.

If Mickey befriended the foe, the chest contains Goofy's Torso. If he killed him, the chest contains a Gold Pin.