Health Refills are power-ups that can be found in Epic Mickey and Epic Mickey 2: The Power of Two. As the name suggests, they refill Mickey's health. They resemble a pink version of Mickey's head with a white heart in the main "head". They come from defeated enemies or from breakable/painted objects. Some refills offer more than one pip of regeneration, up to three. If they're not collected, they start to shrink and disappear, though shrunken Health Refills don't refill less health.
- In Epic Mickey 2: The Power of Two, the item sometimes disappears immediately and without warning. The reason for this is unknown, though it is possible that it is a glitch.